Vasopresina vs. epinefrina en la resucitación cardiopulmonar y cerebral.

Marta Sofia López Rodríguez, Alejandro Jesús Areu Regateiro, Maykel D Ruiz Gorrin

Texto completo:

PDF

Resumen

La epinefrina ha sido la droga de mayor intervención en el paro cardiorrespiratorio por lo que ha sido objeto de múltiples Investigaciones en animales y humanos El descubrimiento
de la respuesta presora de las catecolaminas y la respuesta hormonal con liberación de corticotropina, cortisol y vasopresina en sujetos sometidos a reanimación cardiopulmonar y cerebral., ha verificado la correlación existente entre los niveles endo genos de vasopresina y el retorno a la circulación espontánea y sorprendentemente la escasa probabilidad de supervivencia cuando existen niveles altos de catecolaminas. Esto nos motivo a realizar una revisión practica, sencilla y actualizada sobre las acciones que presentan la vasopresina vs epinefrina sobre el flujo sanguíneo coronario, flujo sanguíneo renal y cerebral durante la preanimación cardiopulmonar y cerebral basado en estudios experimentales en animales y humanos. La Vasopresina apoyada en los estudios es una nueva alternativa en el tratamiento del paro cardiacorespiratorio pero la epinefrina continua siendo la droga de elección.

Palabras clave

resucitacion cardiopulmonar; vasopresina; epinefrina; perfusion

Referencias

-Pérez Vela, JL., Perales y Rodríguez de Viguri N., Cantalapiedra Santiago JA., Alvarez

Fernández JA.. Recomendaciones en resucitación cardiopulmonar.En Principios de

Urgencias y emergencias de cuidados críticos..2000:1 -2

- Lindner KH, Strohmenger HU, Engineer H, Hazel WD, Handfed FW, Georgia M. Stress

hormone response during and after cardiopulmonary resuscitation. Anesthesiology.

;77:662-668.

- Lindner KH, Haak T, Keller A, Bothner U, Lurie KG. Release of endogenous

vasopressors dur ing and after cardiopulmonary resuscitation. Heart. 1996;75:145-150.

- Brown CG, Martin DR, Pepe PE, Stueven H, Cummins RO, Gonzalez E, Jastremski M.

A comparison of standard-dose and high-dose epinephrine in cardiac arrest outside the

hospital. N Engl J Med. 1992;327:1051-1055.

- Lindner KH, Prengel AW, Strohmenger HU, Lurie KG. Vasopressin administration in

refractory cardiac arrest. Ann Intern Med. 1996;124:1061-1064.

- Song L, Weil MH, Tang W, Sun S, Pellis T. Cardiopulmonary resuscitation in the

mouse. J Appl Physiol 2002; 93(4):1222-6.

- Paradis NA, Martin GB, Rivers EP, Goetting MG, Appleton TJ, Feingold M, Coronary

perfusion pressure and the return of spontaneous circulation in human cardiopulmonary

resuscitation. JAMA 1990 .263(8):1106-13

- Kern KB, Lancaster L, Goldman S, Ewy GA. The effect of coronary artery lesions on

the relationship between coronary perfusion pressure and myocardial blood flow during

cardiopulmonary resuscitation in pigs. Am Heart J .1990;120(2):324-33

--Hoffman BB, Lefkowitz. Cathecholamin sympatimomimetic drugs and adrenergic

receptor antagonist.In Goodman Gilman A.The pharmacological basis of

therapeutic.1995.Interamerican eds.:200-1.

-Yakaitis RW, Otto CW, Blitt CD. Relative importance of alpha and beta adrenergic

receptors dur ing resuscitation. Crit Care Med 1979; 7:293-296

-. Berg RA, Otto CW, Kern KB, Hilwig RW, Sanders AB, Henry CP, Ewy GA. A

randomized, blinded trial of high-dose epinephrine versus standard-dose epinephrine in a

swine model of pediatric asphyxial cardiac arrest. Crit Care Med 1996;24:1695-1700

Hornchen U, Lussi C, Schuttler J. Potential risks of high-dose epinephrine for

resuscitation from ventricular fibrillation in a porcine model. J Cardiothorac Vasc Anesth

;7:184-187

-. Neumar RW, Bircher NG, Sim KM, Xiao F, Zadach KS, Radovsky A, Katz L,

Ebmeyer E, Safar P. Epinephrine and sodium bicarbonate during CPR following asphyxial

cardiac arrest in rats. Resuscitation 1995; 29:249-263

- Schmitz B, Fischer M, Bockhorst K, Hoehn-Berlage M, Hossmann KA. Resuscitation

from cardiac arrest in cats: influence of epinephrine dosage on brain recovery.

Resuscitation1995;30:251-262

-. Rivers E, Wortsman J, Rady M, Blake H, McGeorge F, Buderer N. The effect of the

total cumulative epinephrine dose administered during human CPR on hemodynamic,

oxygen transport, and utilization variables in the postresuscitation period. Chest

;106:1499-1507

-. Behringer W, Kittler H, Sterz F, Domanovits H, Schoerkhuber W, Holzer M, Mullner

M, Laggner AN. Cumulative epinephrine dose during cardiopulmonary resuscitation and

neurologic outcome . Ann Intern Med 1998; 129:450-456

--Jackson EK.Vasopressin and other agents affecting the renal conservation of water. In

Goodman Gilman A. The pharmacological basis of therapeutic.1995

.Interamerican eds.:269-271.

- Wenzel V, Krismer AC, Voelckel WG.The use arginine vasopressin during

cardiopulmunary resuscitation.An análisis of experimental and clinical experience and a

view of the future.Anaesthesist;2002;51(3):191-202.

- Wenzel V, Lindner KH.Arginine vasopressin during cardiopulmonary resuscitation:

Laboratory evidence, clinical experience and recommendation, and a view to the future.Crit

Care Med: 2002; 30(4):157-161.

Wenzel V, Lindner KH; Baubi MA.Vasopressin decrease endogenous cathecholamine

plasma concentration during cardiopulmonary resuscitation en pigs.Crit Care

Med;2000(4):1236-8.

-Krismer Ac, Lindner KH,Wenzel V.The effect of endogeneous and exogenous

vasopressin during experimental cardiopulmonary resuscitation.Anesth

Anal;2001;92(6):1499-504.

-Chugs SS, Lurie kG,Lindner Kh.Using vasopressing in cardiopulmonary

arrest.Circulation;1997;96:2453-6.

-Voelckel WG, Lurie KG, Mc Knite S. Effect of epinephrine and vasopressin in a piglet

model of prolonged ventricular fibrillation ans cardiopulmonary resuscitation. Crit Care

Med;2002;30(5):1158-9.

-Wenzel V, Lindner Kh. Prengel AW. Vasopressin improve vital organ flow after

prolonged cardiac arrest with ppost countershock pulseless elecytrical activity in pigs.Crit

Care Med;1999;27(3):441-50.

- Wenzel V, Lindner KH, Krismer Ac.Survival with full neurologic recovery and no

cerebral pathology after prolonged cardiopulmonary with vasopressin in pigs.JAM.Coll

Cardiol;2000; (5):27-33.

--Prengel Aw, Lindner Kh; Keller A, Lurie KG.Cardiovascular function during the

postresuscitation phase after cardiac arrest in pigs:a comparinson of epinephrine vs

vasopressin.Crit Care Med;1996;24(12):2014-9.

- Babar SI, Berg RA, Hilwig RW.Vasopressin vs. epinephrin e during cardiopulmonary

resuscitation; a randomized swine outcome study. Resuscitation; 1999; 41(2):185-192.

-Wenzel V, Ewy GA, Lindner KH.Vasopressin and endothelin during cardiopulmonary

resuscitation.Crit Care Med,2000; 28(11)233-5.

-Nozari A, Rubertsson S, Wiklud L..Differences in the pharmacodynamic of epinephrine

and vasopressin during and after experimental cardiopulmonary

resuscitation.Resuscitation,2002;49(1):59-72.

--Morris DC, Dereczyk BE, Grzybowski M. Vasopressin can increase coronary perfusion

pressure during human cardiopulmonary resuscitation. Acad Emerg Med 1997;20:609-614

-Wenzel V, Lindner Kh;Krismer Ac.Repeated administration of vasopressin but no

epinephrine maintains coronary perfusion pressure after early and late administration

during prolonged cardiopulmonary resuscitation in pigs.Circulation;1999;99:1379-1384.

- Lindner KH, Dirks B, Strohmenger HU, Prengel AW, Lindner IM, Lurie KG.

Randomized comparison of epinephrine and vasopressin in patients in out-of-hospital

ventricular tachycardia. Lancet. 1997;349:535-537.

-Lindner KH, Brinkmann A, Pfenninger EG, Lurie KG, Goertz A, Lindner IM. Effect of

vasopressin on hemodynamic variables, organ blood flow and acid -base status in a pig

model of cardiopulmonary resuscitation. Anesth Analg. 1993;77:427-435.

-Lindner KH, Prengel AW, Pfenninger EG, Lindner IM, Strohmenger HU, Georgieff M,

Lurie KG. Vasopressin improves vital organ blood flow during closed-chest

cardiopulmonary resuscitation in pigs. Circulation. 1995;91:215-221.

- Wenzel V, Lindner KH, Augenstein S. Vasopressin combined with epinephrine

decreases cerebral perfusion compared with vasopressin alone during CPR in pigs. Stroke

;29:1467-1468

- Voelckel WG, Lindner KH, Wenzel V.Effect of vasopressin and epinephrine on

splanchic blood flow and renal function during and after cardiopulmonary resuscitation in

pig.Crit Care Med;2000;28(4):1083-8

-Wenzel V,Lindner Kh,Augenstein S.Vasopressin combined with epinephrine decrease

cerebral pressure compared with vasopressin alone during cardiopulmonary resuscitation

in pigs.Stroke;1998;29:1462-8.

-Mulligan KA, McKnite SH, Lindner Kh.Synergistic effects of vasopressin plus

epinephrine during cardiopulmonary resuscitation.Resuscitation ;1997;35(3) 269-271.

-Achllleitner V, Wenzel V,Strohmenger HV.The effect of repeated dose of vasopressin

or epinephrinein ventricular fibrillator in a porcine model of prolonged cardiopulmonary

resuscitation.Anesth Analg;2000;90(5):1067-75.

- Amann, A., Rhe inberger, K., Achleitner, U., Krismer, A. C., Lingnau, W., Lindner, K.

H., Wenzel, V. The Prediction of Defibrillation Outcome Using a New Comb ination of

Mean Frequency and Amplitude in Porcine Models of Cardiac Arrest. Anesth Analg

;2002;95: 716-722

-Kern KB, Halperin HR, Field J..New Guidelines for cardiopulmonary resuscitation and

emergency care.Change in the management of cardiac arrest.JAMA.2001;285(10):1267-9

-Kono S, Bito H, Susuki A.Vasopressin and epinephrine are equally effective for CPR in

a rat model.Resuscitation ;2002 52(2):215-9.

Enlaces refback

  • No hay ningún enlace refback.




Licencia de Creative Commons
Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial 4.0 Internacional.